[醫如往常] Senior Clerkship Day 113: Pathology: sarcoma

Microconference
張醫師


Ewing like sarcoma
Round cell sarcoma
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CIC rearranged sarcoma
DUX4L
T(4;19)
T(10:19)


Ddx: BCOR-CCMB3
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CIC, Repressor in RTK
DUX4 double homeobox


ETV1,4, FEV


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Young adult
Soft tissue
Chemoresistance
Worse prognosis


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Diffuse and lobular architecture
Microcysts
Myxoid
Desmoplasia
Vesical chromatin
Amphophilic cytoplasm
Geographic necrosis
Perivascular cuff
Vague storiform
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Pleomorphism
Prominent nucleoli
Mitotic index
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CD99在 Ewing sarcoma membrane
Ewing 不會WT1


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CIC1 sarcoma
ETV4 87%+
NKX2-2  -
WT1 95+.  C-terminals
ETV4 90%+
Calretinin focal
Cd99 focal
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Ewing sarcoma
CD99 +
NKX2-2 84%+
WT1 -
ETV4 -
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BCOR sarcoma
CD99 -
WT1 -
ETV4 -
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Unclassified round cell sarcoma


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DUX4
在B cell ALL , Rhabdomyosarcoma 也可能發現
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