CLSI AST
Breakpoints
Antibiotic
sensitivity test
劉醫師
Class ABC 藥物
O 研究藥物
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Disk dilution method 只會給大小，
不知道MIC
Broth
dilution method
E test 用濾紙
Vitek
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BAP Agar
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MIC
minimal inhibitory concentration
- MIC50
- MIC90
- Mic epidemiological distribution, cutoff value (wild, mutant )
MBC
minimal bactericidal concentration
MPC mutation
prevention concentration
Serum
bactericidal titer , for infective endocarditis
- 一週沒改善，就要開刀去除biofilm
- 現在很少做SPT
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Epidemiology
Pharmaceutical
consideration
- Time>MIC越久越好
- Cmax/MIC
Clinical
evaluation
Post market
surveillance PMS
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Inhibitory quotient
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Post antibiotics effect
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Clinical success
USA 90%
ROC 80%
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Correlation
Oxacilin
correlation很差，要用cefazolin做disk dilution
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現在有些標誌會改變4→2
但機器只能做到<4
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Intracellular bacteria做出來有效，
實際還是無效
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不能穿過BBB
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鄭醫師
Maryland general hospital
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雪梨宣言
Statement of death
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ISO 15189
Lab ethics
http://www.taftw.org.tw/wSite/ct?xItem=334&ctNode=177&mp=1
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每分鐘20管
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H. Pylori test
H. Pylori test
紅外線200萬
質譜儀700萬
成本六百元
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False positive
Urease producing bacteria
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False negative
PPI
Gastic
surgery
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Occult blood test
Occult blood test
Chemical test10元 GI
- Vit C false negative
Immunochemistry
70元 low GI
健保50點
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CA 72.4 gastric cancer, gastritis
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HCC, F18沒有用
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CA19-9
HbA1C升高也會高
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邵醫師
Galactomannan GM
Aspergillosis
Blood
Broncho
lavage BAL 最敏感
CSF
Detect GAF
tetramer
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CGD, chronic granumatous disease
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False positive
Antibiotics,
Other mycosis
比菲德氏菌
False negative
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Plasma
Serum
BAL
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Population 決定ppv,npv
常跟論文結果相反 ，
因為族群不同，論文大多是探討screening
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Elisa
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Fungus PCR去年上市
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沒有留言:
張貼留言
歡迎指教