[醫如往常] Senior Clerkship Day 118: Pathology: Collagen

 Collagen 郭醫師

• Type I: skin, tendon, vascular ligature, organs, bone (main component of the organic part of bone)
• Type II: cartilage (main collagenous component of cartilage)
• Type III: reticulate (main component of reticular fibers), commonly found alongside type I.
• Type IV: forms basal lamina, the epithelium-secreted layer of the basement membrane.
• Type V: cell surfaces, hair and placenta
• Type VII: anchor of epithelial cells

來自 <https://en.wikipedia.org/wiki/Collagen>

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https://www.google.com/patents/WO2006026652A2?cl=en

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Liver 4-6X chromosomes

Fresh-> oil red

Eosinophil 雙折光

mast cell 荷包蛋

Basophil 核被granules cover

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van Gieson's stain (double stain)

Acidic 環境下染collagen, 不染smooth muscle

Nuclear用Weigert's iron hematoxylin 才不會洗掉

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Masson trichrome (三種染劑)

Biebrich’s scarlet (猩紅)染所有的東西變成紅色

接著用conjunction with phosphotungstic (燐鎢酸) or phosphomolybdic acid (燐鉬酸)洗掉

最後染aniline blue (苯胺藍)